Automated medical image segmentation suffers from high inter-observer variability, particularly in tasks such as lung nodule delineation, where experts often disagree. Existing approaches either collapse this variability into a consensus mask or rely on separate model branches for each annotator. We introduce ProSona, a two-stage framework that learns a continuous latent space of annotation styles, enabling controllable personalization via natural language prompts. A probabilistic U-Net backbone captures diverse expert hypotheses, while a prompt-guided projection mechanism navigates this latent space to generate personalized segmentations. A multi-level contrastive objective aligns textual and visual representations, promoting disentangled and interpretable expert styles. Across the LIDC-IDRI lung nodule and multi-institutional prostate MRI datasets, ProSona reduces the Generalized Energy Distance by 17% and improves mean Dice by more than one point compared with DPersona. These results demonstrate that natural-language prompts can provide flexible, accurate, and interpretable control over personalized medical image segmentation. Our implementation is available online 1 .

Deep learning is expected to aid pathologists by automating tasks such as tumour segmentation. We aimed to develop one universal tumour segmentation model for histopathological images and examine its performance in different cancer types. The model was developed using over 20 000 whole-slide images from over 4 000 patients with colorectal, endometrial, lung, or prostate carcinoma. Performance was validated in pre-planned analyses on external cohorts with over 3 000 patients across six cancer types. Exploratory analyses included over 1 500 additional patients from The Cancer Genome Atlas. Average Dice coefficient was over 80% in all validation cohorts with en bloc resection specimens and in The Cancer Genome Atlas cohorts. No loss of performance was observed when comparing the universal model with models specialised on single cancer types. In conclusion, extensive and rigorous evaluations demonstrate that generic tumour segmentation by a single model is possible across cancer types, patient populations, sample preparations, and slide scanners.

Rationale and Objectives: To develop and validate PARROT (Polyglottal Annotated Radiology Reports for Open Testing), a large, multicentric, open-access dataset of fictional radiology reports spanning multiple languages for testing natural language processing applications in radiology. Materials and Methods: From May to September 2024, radiologists were invited to contribute fictional radiology reports following their standard reporting practices. Contributors provided at least 20 reports with associated metadata including anatomical region, imaging modality, clinical context, and for non-English reports, English translations. All reports were assigned ICD-10 codes. A human vs. AI report differentiation study was conducted with 154 participants (radiologists, healthcare professionals, and non-healthcare professionals) assessing whether reports were human-authored or AI-generated. Results: The dataset comprises 2,658 radiology reports from 76 authors across 21 countries and 13 languages. Reports cover multiple imaging modalities (CT: 36.1%, MRI: 22.8%, radiography: 19.0%, ultrasound: 16.8%) and anatomical regions, with chest (19.9%), abdomen (18.6%), head (17.3%), and pelvis (14.1%) being most prevalent. In the differentiation study, participants achieved 53.9% accuracy (95% CI: 50.7%-57.1%) in distinguishing between human and AI-generated reports, with radiologists performing significantly better (56.9%, 95% CI: 53.3%-60.6%, p<0.05) than other groups. Conclusion: PARROT represents the largest open multilingual radiology report dataset, enabling development and validation of natural language processing applications across linguistic, geographic, and clinical boundaries without privacy constraints.

Rare gynecological tumors (RGTs) present major clinical challenges due to their low incidence and heterogeneity. The lack of clear guidelines leads to suboptimal management and poor prognosis. Molecular tumor boards accelerate access to effective therapies by tailoring treatment based on biomarkers, beyond cancer type. Unstructured data that requires manual curation hinders efficient use of biomarker profiling for therapy matching. This study explores the use of large language models (LLMs) to construct digital twins for precision medicine in RGTs. Our proof-of-concept digital twin system integrates clinical and biomarker data from institutional and published cases (n=21) and literature-derived data (n=655 publications with n=404,265 patients) to create tailored treatment plans for metastatic uterine carcinosarcoma, identifying options potentially missed by traditional, single-source analysis. LLM-enabled digital twins efficiently model individual patient trajectories. Shifting to a biology-based rather than organ-based tumor definition enables personalized care that could advance RGT management and thus enhance patient outcomes.

Background and purpose: The unanticipated detection by magnetic resonance imaging (MRI) in the brain of asymptomatic subjects of white matter lesions suggestive of multiple sclerosis (MS) has been named radiologically isolated syndrome (RIS). As the difference between early MS [i.e. clinically isolated syndrome (CIS)] and RIS is the occurrence of a clinical event, it is logical to improve detection of the subclinical form without interfering with MRI as there are radiological diagnostic criteria for that. Our objective was to use machine-learning classification methods to identify morphometric measures that help to discriminate patients with RIS from those with CIS. Methods: We used a multimodal 3-T MRI approach by combining MRI biomarkers (cortical thickness, cortical and subcortical grey matter volume, and white matter integrity) of a cohort of 17 patients with RIS and 17 patients with CIS for single-subject level classification. Results: The best proposed models to predict the diagnosis of CIS and RIS were based on the Naive Bayes, Bagging and Multilayer Perceptron classifiers using only three features: the left rostral middle frontal gyrus volume and the fractional anisotropy values in the right amygdala and right lingual gyrus. The Naive Bayes obtained the highest accuracy [overall classification, 0.765; area under the receiver operating characteristic (AUROC), 0.782]. Conclusions: A machine-learning approach applied to multimodal MRI data may differentiate between the earliest clinical expressions of MS (CIS and RIS) with an accuracy of 78%. Keywords: Bagging; Multilayer Perceptron; Naive Bayes classifier; clinically isolated syndrome; diffusion tensor imaging; machine-learning; magnetic resonance imaging; multiple sclerosis; radiologically isolated syndrome.

The potential of artificial intelligence (AI) in digital pathology is limited by technical inconsistencies in the production of whole slide images (WSIs), leading to degraded AI performance and posing a challenge for widespread clinical application as fine-tuning algorithms for each new site is impractical. Changes in the imaging workflow can also lead to compromised diagnoses and patient safety risks. We evaluated whether physical color calibration of scanners can standardize WSI appearance and enable robust AI performance. We employed a color calibration slide in four different laboratories and evaluated its impact on the performance of an AI system for prostate cancer diagnosis on 1,161 WSIs. Color standardization resulted in consistently improved AI model calibration and significant improvements in Gleason grading performance. The study demonstrates that physical color calibration provides a potential solution to the variation introduced by different scanners, making AI-based cancer diagnostics more reliable and applicable in clinical settings.

Neil Thomas wished he could have been awake during the operation to remove a 6cm cancerous tumour from his colon. He was one of the first people to go under the scalpel of University Hospital of Wales's new robotic systems in June 2022. Thomas's surgeon, James Ansell, would once have stooped over his patient's body to perform the operation. Instead, he stood behind a console on another side of the theatre wearing 3D glasses. His hands grasped two joysticks, which controlled the four robotic arms that huddled around Thomas's unconscious body.

Early detection of colon cancer thanks to funds provided by the State Research Agency (AEI), an agency of the Ministry of Science and Innovation, which promotes scientific and technological research in all areas of knowledge through efficient allocation of public resources Leading project to install . Researchers from the University of Vigo and the Hospital Universitario de Ourense have developed an innovative detection system for colorectal polyps that uses artificial intelligence (AI) to detect them, as well as diagnose their degree of malignancy in real time, whether they are benign or tumor. The PolyDeep project started in 2018, promoted by the State Program Oriented to Society's Challenges, and ends in 2021. In total, the budget given to the project is 127,171 Euros and it is co-financed with the European Federated Fund and the Recovery, Transformation and Resilience Plan. The initiative is led by researchers Miguel Rebeiro Jato and Daniel González Peña from the New Generation Computer Systems (SING) group of Ourense Higher School of Computer Engineering, University of Vigo, in collaboration with the Research Group in Digestive Oncology.

PARIS, November 21, 2022 – A team of experts at Capgemini, in collaboration with University Hospital Bonn and Amazon Web Services, has developed an artificial intelligence (AI) model that will accelerate the speed of clinical trials aiming to establish new treatments for River Blindness, a neglected tropical disease which affects over 20 million people globally[1]. Currently, the specialist work of clinical trials can only be carried out manually by a handful of global experts, so the winning model could save years of work and speed up the development of new treatments. The India-based winning team developed a model which harnesses deep learning technology to identify the larvae worm that causes River Blindness, using images from existing clinical studies. In total, over 70,000 sections of clinical data were utilized to train the AI, leading to the creation of a model that can identify worm sections in microscopic images with almost 90% accuracy. The ability to automate such a high proportion of the required analysis will unlock the potential of faster and more consistent assessment of the efficacy of new drugs, which could save the eyesight of sufferers worldwide.

According to the Global Burden of Disease list provided by the World Health Organization (WHO), mental disorders are among the most debilitating disorders.To improve the diagnosis and the therapy effectiveness in recent years, researchers have tried to identify individual biomarkers. Gathering neurobiological data however, is costly and time-consuming. Another potential source of information, which is already part of the clinical routine, are therapist-patient dialogues. While there are some pioneering works investigating the role of language as predictors for various therapeutic parameters, for example patient-therapist alliance, there are no large-scale studies. A major obstacle to conduct these studies is the availability of sizeable datasets, which are needed to train machine learning models. While these conversations are part of the daily routine of clinicians, gathering them is usually hindered by various ethical (purpose of data usage), legal (data privacy) and technical (data formatting) limitations. Some of these limitations are particular to the domain of therapy dialogues, like the increased difficulty in anonymisation, or the transcription of the recordings. In this paper, we elaborate on the challenges we faced in starting our collection of therapist-patient dialogues in a psychiatry clinic under the General Data Privacy Regulation of the European Union with the goal to use the data for Natural Language Processing (NLP) research. We give an overview of each step in our procedure and point out the potential pitfalls to motivate further research in this field.